微导管应用：栓塞微粒(2)


Hand-cut	Pumping

Dr. Miyuki Sone

GS Is Biodegradable

一般在1-3周内吸收..Typically absorbed in 1-3 weeks.

慢性炎症可导致血管狭窄或阻塞 Vessel stenosis or occlusion can occur due to chronic inflammation

Nippon Kayaku Co. Ltd

 Calibrated microspheres

 Bland

 Drug-eluting

对常规栓塞微粒缺点的对应，90年代发展起来的栓塞微粒 Developed since 1990’s in response to drawbacks of conventional particles
表面光滑的惰性合成聚合物 Inert synthetic polymer with a smooth surface
栓塞微粒的粒径均匀一致 Homogenous particle size
可压缩 - 轻松通过微导管 Compressible --- easy microcatheter passage
药物荷载 Drug-loadable


Homogeneous size	Compressed spheres in a microcatheter

Bland-beads （40-1200μm）


Embosphere	BeadBlock	Embozene

Drug-eluting beads（30-700μm）


HepaSphere	DC-Bead	Tandem

与PVA/GS比较，微粒可以在血管内行进到更末梢的血管 Microspheres travel far distally compared with PVA/GS
一个微粒可以阻塞蒸锅血管腔 A single particle occupies entirely a vessel lumen
阻塞水平和微粒的粒径相关 Occlusion level is well correlated with particle size.

可以预期和控制阻塞的水平 Prediction and control of occlusion level

靶向栓塞减少正常组织的损伤 Targeted embolization to minimize normal tissue damage


mbosphere 100-300 μm

Deep Penetration of Microspheres：Case: Nasal angiofibroma